The Science Behind Testosterone Boosting Supplements

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The issue, says the agency, is the product uses "sulfoaildenafil, a chemical similar to sildenafil, the active ingredient in Viagra." Like Viagra, sulfoaildenafil can have dangerous interactions with other prescription drugs such as nitrates, and can cause dangerously low blood pressure. But because consumers think they are taking a "natural" product they are usually not under a doctor's care. Also, sulfoaildenafil has not undergone the same clinical trials as sildenafil, so all its effects are not known.

Customer Rating (out of 5) Percentage of Users Product Examples Main Benefits
4-5 70-80% Viagra, Cialis Quick effect, reliable
2-3 10-20% Herbal supplements Mild effects, safer for daily use
1 5-10% Some herbal pills No effect or adverse reactions

It's not clear if "Stiff Nights" is a "dietary supplement" as its maker claims, or a bad b-movie title, but in either case the FDA says men looking to "regain the thunder" should stay clear because the pill really contains sulfoaildenafil, an untested chemical similar to the active ingredient in Viagra, which can interact badly with nitrates and cause low blood pressure.FDA Warning.

Factor Impact Notes
Dosage Higher dose can increase effect But also increases side effects
Timing of intake Timing before sexual activity Usually 30-60 minutes prior
Food consumption High-fat meals delay absorption Best taken on empty stomach or light meal
Individual health status Underlying conditions may reduce efficacy Consult a doctor

The marketing geniuses behind "Stiff Nights" also sell "Rock Hard Weekend." Same unregulated chemical, says the FDA, different laugh out loud brand. It's not clear who Don Wands is or how he became so magical, but the FDA didn't seem to care.

  • Sildenafil is a PDE5 inhibitor commonly prescribed for erectile dysfunction.
  • L-arginine works as a precursor to nitric oxide, enhancing blood flow.
  • Ginseng acts as a natural adaptogen improving stamina and sexual vigor.
  • Horny goat weed improves libido and sexual function through icariin content.
  • DHEA naturally declines with age, and supplementation may restore libido.
  • Zinc deficiency can impair testosterone production, supplements help restore it.
  • Tribulus terrestris may improve sexual desire by modulating hormones.
  • Yohimbine shares benefits for ED but can cause side effects like anxiety.
  • Maca root is used for increasing sexual desire and reducing fatigue.
  • Fenugreek is investigated for boosting testosterone and sexual function.
  • L-citrulline enhances nitric oxide, promoting stronger erections.

In August 2010, they told the manufacturer of this supplement to drop the magic act and take it off the shelves because the product's two main ingredients, hydroxyhomosildenafil and sulfoaildenafil, aren't listed on the box, aren't "supplements" and aren't really tested.FDA Warning. Magic Power Coffee's website says the extra mojo comes from honey goat weed and goji berries.

  • Sildenafil (Viagra) is a well-known drug to treat erectile dysfunction effectively.
  • L-arginine increases nitric oxide which relaxes blood vessels for erection.
  • Tribulus terrestris is used as a natural libido booster with some evidence.
  • Horny goat weed's active compound icariin improves erectile function.
  • Ginseng helps reduce fatigue and boost sexual endurance and performance.
  • Maca improves sexual desire and reduces anxiety related to sex.
  • DHEA may help restore natural hormone levels impacting libido.
  • Fenugreek may support testosterone levels and sexual desire.
  • Zinc is crucial for male sexual health, aids in hormone production.
  • L-citrulline supports nitric oxide production enhancing erections.
  • Yohimbine improves blood flow and nerve signaling for erectile quality.

If you wind up with Duro Extend in your stocking this year, you might want to send it back to Santa. The FDA recalled the product in early December 2010 because the "dietary supplement" is secretly supplemented with sulfoaidenafil, a drug similar to Viagra, but not tested.

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FDA issues new safety rules for vitamins. Zwillich T. FDA OKs dietary supplement regulations. Center for Science in the Public Interest. Cohen B, Schardt D.

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Letter to The Honorable Deborah P. Majoras. Enzyte is trusted by over 3 million users and is the #1 selling supplement in the world for natural male enhancement. Marketer of "enhancement" lovegra tablet pill Enzyte to pay restitution, change practices in settlement over negative option plan. Attorney General Lockyer announces settlement requiring maker of "Smiling Bob" erectile dysfunction product to provide consumers restitution.

Why do doctors recommend male enhancement pills?

AG sues herbal supplement company for misleading Oregonians about the pills' effectiveness and the "free" trial offer. Berkeley Premium Nutraceuticals, six individuals indicted for fraudulent business practices in connection with sales of dietary supplements. Kyo-Green improves sexual dysfunction in men and women. The effects of ArginMax, a natural dietary supplement for enhancement of male sexual function. To comment on this article, contact editor@uspharmacist.com. "This product is dangerous to consumers because it claims to contain only natural ingredients when it actually contains a prescription drug ingredient," says the FDA's warning letter.

  • Sildenafil citrate improves blood flow to the penis to help achieve and maintain erections.
  • L-arginine is an amino acid that boosts nitric oxide production, enhancing blood circulation.
  • Yohimbine is derived from tree bark and may improve erectile function.
  • Maca root originates from Peru, supports libido and stamina.
  • Tribulus terrestris is believed to increase testosterone levels and sexual desire.
  • Ginseng is known for reducing fatigue and enhancing sexual performance.
  • Horny goat weed contains icariin, which may help treat erectile dysfunction.
  • Zinc supplements support testosterone production and sperm health.
  • Phenylethylamine (PEA) can increase mood and sexual excitement.
  • Muira puama is traditionally used to boost sexual energy and libido.
  • DHEA supplements may help improve sexual function by balancing hormones.

Dangerous interactions with nitrates and low blood pressure are possible.

Product Type Average Cost per Dose Cost Range (per pack) Notes
Prescription PDE5 inhibitors $10-$30 $50-$100 for a pack of 4 Varies by brand and healthcare system
Herbal Supplements $2-$5 $20-$50 for a month supply Less regulated and variable in potency
Generic versions $5-$15 $20-$60 Often cheaper than brand-name medications

The FDA doesn't recommend hitting up Luong for pills, however. They say Vitalex's "all natural" and "herbal" concoction is really acetildenafil, another chemical similar to the drug in Viagra, but not tested. Eager men trying to get their hands on a box of Xiadafil VIP, might have to wait in line.

Product Dosage Quantity + Bonus Price
Viagra Oral Jelly100mg90 + 8 Sachets258.02€ 245.73€
Cialis Professional20mg90 + 2 Pills241.49€ 229.99€
Viagra Generic200mg120 + 8 Pills204.80€ 195.05€
Tadalista Super Active20mg270 + 30 Pills661.49€ 629.99€
Levitra Soft Tabs20mg270 + 10 Pills521.78€ 496.93€
Kamagra 100 mg100 mg84 + 6 Pills264.44€ 251.85€
Kamagra Soft Tabs100mg20 Pills79.79€ 75.99€
Cialis Generic10mg90 + 6 Pills146.17€ 139.21€
Levitra Original20mg64 + 4 Pills298.45€ 284.24€
Kamagra Soft Tabs100mg272 + 12 Pills593.42€ 565.16€
Kamagra Polo100mg84 + 4 Pills244.49€ 232.85€
Viagra Professional100mg20 Pills71.14€ 67.75€

Marshals seized almost $75,000 worth of it after the manufacturer refused an FDA request to recall it. The FDA says the product's VIP power comes from hydroxyhomosildenafil, a drug similar to Viagra, but untested.

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Marketing hype and high profits should never override the pharmacist's professional responsibility to demand proof of safety and efficacy in the products we recommend. Patients experiencing andropause deserve a pharmacist who will refer them for legitimate medical care rather than selling them products that lack proof of efficacy and safety. Available at: Accessed June 29, 2007.2. New York, NY: The Haworth Press, Inc.; 2003.3. Andropause: endocrinology, erectile dysfunction, and prostate pathophysiology.

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Oral andro-related prohormone supplementation: do the potential risks outweigh the benefits? Available at: Accessed June 29, 2007.6. FDA warns consumers about dangerous ingredients in "dietary supplements" promoted for sexual enhancement. Available at: Accessed June 29, 2007.7. Available at: Accessed June 29, 2007.8.

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Final rule promotes safe use of dietary supplements. Available at: Accessed June 29, 2007.9. Final rule for current good manufacturing practices (CGMPs) for dietary supplements. Dietary supplement current good manufacturing practices (CGMPs) and interim final rule (IFR) facts. Freking K. Erectile dysfunction, also called ED, is trouble getting and keeping an erection that's firm enough for sex.

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The FDA's Final Rule In June 2007, the FDA announced a final rule establishing regulations for the current good manufacturing practices (CGMP) of dietary supplements, partly due to the 2006 study of sexual enhancement/impotence products.7-11 Henceforth, the FDA's new CGMPs will ensure that supplements are produced in a quality manner, do not contain contaminants or impurities, and are accurately labeled. The rule is effective as of August 24, 2007, for large businesses and somewhat later for small businesses. Watchdog groups immediately pointed out that supplement manufacturers have never been required to prove their products are safe and effective, and the new regulations also fail to require this fundamental evidence of quality.12 An expert quoted by ABC News stated, "Knowing you have pure and well-made useless crap is a little better than having impure useless crap, but not by much. The Enzyte Scandal While many marketers are in steep competition to capture a share of this lucrative business, one has managed to rise above the others, with its ubiquitous "Smiling Bob" Enzyte ads. This marketer has capitalized on the current thinking that an unproven dietary supplement can easily cure or treat a serious medical condition such as impotence.

Why Are They Taken?

Early ads promised that Enzyte would add as much as three inches to the length of the user's penis.14 Web site testimonials also claim such benefits as allowing stronger, firmer, and easier-to-achieve erections, assisting in maintaining a fully hard erection, providing full and satisfying erections, and reversing the normal erectile problems of aging.15-19 Enzyte contains many ingredients, none of which is FDA-proven to be safe or effective in accomplishing its advertised purposes. These ingredients include niacin, zinc, copper, Korean red ginseng root, ginkgo, pine bark, Tribulus terrestris, arginine, Avena sativa, horny goat weed, maca root, muira puama, saw palmetto, and Swedish flower pollen.20,21 The Cincinnati-based marketer of Enzyte, Berkeley Nutraceuticals, was reported in 2004 by a Cincinnati newspaper to be the subject of over 3,700 consumer complaints.22 In early 2006, Berkeley and its subsidiaries reached a settlement with the attorneys general of 18 states and Washington, D.C. in which it would pay $2.5 million and provide restitution to customers for unsubstantiated claims about the efficacy of their products.23-25 The $2.5 million settlement was a burden easily borne by the company, as it may have reaped as much as a quarter of a billion dollars in 2004 alone through sales of Enzyte and 14 other unproven supplements.26 Later in 2006, the U.S. Department of Justice indicted the company and six individuals (including the president and owner) for bilking Americans of at least $100 million.27 Fraudulent business practices included sending consumers supplements they did not order, charging their credit cards without authorization, laundering the money, and mislabeling a product known as Rovicid. Despite the indictments and settlements, the company continues to advertise and sell its products to a public seemingly unaware of the controversy.

What Ingredients Are In Sex Drive Pills?

Quality of Research on Dietary Supplements When research on dietary supplements intended for sexual enhancement appears, it must be scrutinized closely to assess the soundness of the methodology employed. Two such studies explored the abilities of KyoGreen powder (barley, wheat grass, seaweed) for sexual dysfunction in men and women and ArginMax (herbs, vitamins, minerals) to enhance sexual function in males.28,29 While both studies seemed to show positive results, they are rendered virtually useless because neither study used a control group that was administered a placebo for a valid comparison. Unfortunately, much of the research on dietary supplements is hampered by profound flaws such as this that would cause the research to be rejected by the FDA if it were to be submitted through the legitimate new drug application process used for new medications. Lack of evidence about the safety and efficacy of dietary supplements exposes the consumer to unknown health hazards, as these products use ingredients that are of unknown therapeutic benefit. Marketers of these supplements have been known to engage in fraudulent and deceptive practices. ED is common, and treatments such as prescription medicines are available. But maybe you've seen advertisements for herbs or supplements that claim to boost sexual performance.

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Sexual male enhancement, as the euphemism goes, is big business. Last year, Viagra, the pharmaceutical market leader, raked in about $2 billion. That success has spawned a shadow industry of largely unregulated "natural male enhancement," or sex pill, products. But according to the FDA, some of these products aren't natural, aren't tested and some might even be dangerous. Here's a list of 10 sex pill products the FDA issued health warnings about this year or told manufacturers to get them off the shelves. Erectile dysfunction supplements and other natural remedies have long been used in various cultures. But they haven't been studied or tested nearly as much as prescription medicines for ED.